The Birmingham-based university plans to fund the development through the use of European funds, commercial sponsorship, a grant from a regional development agency and its own funds.
The first schemes planned are a £20m extension to Aston Business School's Nelson Building, due to open in 2005, and a £8m building for Aston's Academy of Life Sciences (pictured), due to open in 2004. The first phase of the construction work is to start in the next academic year.
The university said the schemes would link with Birmingham council's plans for the east side of the city centre, bordering the 25 ha site.
The east side regeneration scheme, masterplanned by architect HOK, will have an area set aside for education, which will include the new Matthew Boulton College.