She also warned that the Greater London Authority would act to stop future developments that lacked transport and infrastructure provision.
Gavron said: "I am quite horrified to find that the tower proposal is not coming out with any masterplan. I think it is utterly utterly shocking. We are going to stop that happening."
Paul Finch, a member of the Commission for Architecture and the Built Environment, warned that the scheme could be scuppered without a masterplan. He said: "In the absence of a successful resolution of the public realm aspects of the scheme, it will not happen."
The criticism of the scheme, which is being developed by Irvine Sellar, follows a call by English Heritage for the DTLR to call in the 66-storey tower.
Sir Neil Cossons, chairman of EH, said the building would be a "spike through the heart" of the heritage site.
At the launch of the RIBA's design guidance, which aims to "provide inspiration for better, bolder architecture and urban design in London", Gavron also revealed more of the GLA's draft spatial development plan, due to be released next year.
I am horrified to find that the tower proposal is coming out without any masterplan
Nicky Gavron, deputy mayor of London
She said the authority planned a 15-year programme based on extending the public transport system in the capital to create transport hubs.
She said: "We want improved public transport as a framework and skeleton to hang a series of new developments in London on.
"We want to create a city of interchanges, which will house urban villages. The challenge for the design profession will be how to transform stations into these interchanges."
Gavron also pledged the GLA's support to the wholescale redevelopment of east London.
