The consortiums have been shortlisted by the London Development Agency, the economic development arm of the Greater London Authority, and joint-venture partner Newham council.
The teams are led by Barratt/Bellway; St George; Taylor Woodrow; Wimpey/Countryside; and London and Southern, a regeneration company set up by developers Jack Jacobs and Maurice Pearce and regeneration consultant David Taylor.
They will submit bids to the agency by 20 April.
St George is working with architects Broadway Malyan and Patel Taylor, Wimpey/Countryside has teamed up with Richard Rogers Partnership, and Barratt/Bellway is working with Bath masterplanner Nick Kuhn and London-based Robert McDonald Associates.
London and Southern's consortium includes five architects: Terry Farrell & Partners, Paskin Kyriakides Sands, Maccreanor Lavington, Scott Brownrigg & Turner and Jestico + Whiles. Other team members are project manager GTMS, contractor Kajima and Toronto-based masterplanner Urban Strategies.
The brief for the site is based on an urban framework study carried out by consultant EDAW. It calls for a mixed-use scheme with up to 2218 homes, shops, a hotel, offices, a school and community buildings.
It also suggests a large leisure attraction on the waterfront site, which was previously earmarked for a £90m National Aquarium designed by Farrell in 1996. This was shelved after being refused Millennium Commission funding in 1997. Farrell is understood have dusted down the aquarium designs as part of the London and Southern bid.
London mayor Ken Livingstone last year expressed support for the revival of the aquarium, which would have been the world's largest.
The brief also requires the reuse of two listed buildings – the 40,000 m2 Millennium Mills and Silo D, a vast grain store that, until a recent fire, housed a nightclub. The Millennium Mills may be converted into loft apartments, shops and restaurants and Silo D, which has few windows, could house a leisure development.
Despite being the first large scheme sponsored by the agency, the Silvertown Dock brief has not called for any affordable housing.
A spokesperson for Newham council said the GLA and the council would have to come to a decision on social housing: "The developers are aware that they will have to provide some. But obviously the mayor is looking for more." The development will be served by a new station called Silvertown on a proposed £115m extension of the Docklands Light Railway.
A winner for the scheme will be chosen in summer.